Keep an eye on Closely (1)mitotane decreases levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Mitotane is a solid inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for doable dosage adjustments.Geriatric Use In elderly patients, it is recommended that the dosage be restriā¦ Read More